Custom nucleoside and nucleotide synthesis

NuBlocks has been a leading supplier and service provider of nucleic acid building blocks for pharmaceutical research. Over the several decades of business, we have synthesized thousands of nucleosides and nucleotides, many requiring novel synthetic routes. Our facilities utilizes state-of-the-art equipment alongside a team of professional PhD chemist to deliver a complete range of premium specialty nucleoside synthesis services. We have earned ourselves a reputation for being able to tackle some of the most challenging synethsis in a timely matter. Our team offers clear communication so contact us anytime.

The NuBlocks advantage

At NuBlocks, our custom synthesis approach is rooted in a combination of deep scientific expertise and decades of experience. Our team works closely with clients to understand their specific challenges and needs. With our well equiped labs and novel synthetic processes, we ensure the ability to provide high-quality results.

Novel synthesis

Quality results

Custom molecules for your needs

Every nucleotide has unique chemistry depending on the sugar and base modifications. We have the proper knowledge and equipment to synthesize specific nucleotides you need for your research goals.

Quality and purity ensured

The synthesis is constantly monitored using analytical instruments such as HPLC to ensure purity and stability of the compound. If you give us a lead compound, we will return it after purification.

Accelerate your research

We have partnered with many reserachers to assist in accelerating their research progress. Our efficient synthetic protocols combined with our rapid project turnarounds means your research will continue to move at a fast pace.

NuBlocks synthesis capabiltiies

NuBlocks offers a comprehensive suite of custom nucleoside and nucleotide synthesis services designed to push your research progress forward.

Phosphate: Our phosphate conversion transforms your lead compound into a purified biologically nucleotide.

Sugar: We are able to chemically modify both ribose and deoxyribose based sugars. Different functional groups can increase resistance to enzymatic degradation.

Base: Similar to sugar, functional groups can be used to chemically modify the base. We can customize the nucleobase to offer better target specificity for antiviral or anticancer therapeutics.

Linker: Part of the base modification is the ability to attach various linkers for further attachment of labeling compounds. We have experience using a variety of different linkers with different chain lengths.

Label: Attaching various dye molecules to allow researchers to tag a nucleoside for enhanced detection and analysis. We are fully capable in the chemistry of nucleoside linkers and labels.

Frequently asked synthesis questions

What nucleoside synthesis services do you offer?

We provide a full spectrum of custom nucleoside synthesis services—including phosphate conversion, triphosphates, base modification, sugar modification, novel nucleoside analogs, linkers, labels and custom phosphoramidites.

What is phosphate conversion synthesis?

Phosphate conversion starts with the customer providing a nucleoside compound to be phosphorylated and purified. We are able to make nucleoside monophosphates, diphosphates and triphosphates. A series of synthesis, purification and analysis are performed before the final compound completed.

Nucleoside vs Nucleotide vs Phosphoramidite?

Nucleotides are the building blocks of DNA and RNA, it consists of a nitrogenous base, a pentose sugar and a phosphate. Nucleosides are nucleotides with the phosphate group removed. Phosphoramidites are modified nucleosides with a phosphite ester and other protection functional groups. Phosphoramidites are used in solid state oligonucleotide production.

What are your custom synthesis project timeline?

Depending on the amount and complexity this can vary. Often we aim for a week completion but projects that require large amounts of are challenging synthetically may take several weeks Clear communication channels will be maintained from start to finish. If there are difficulties or better synthetic routes we will discuss them clearly before moving forward.