Crafting Nucleic Acid Building Blocks

NuBlocks specializes in synthesizing custom nucleoside triphosphates and phosphoramidites, empowering your innovative drug development research one molecule at a time. Visit our shop to view our online catalogue or contact us for questions.

Our Customers

Dedicated experts in research and synthesis of nucleobases

Starting in 2005, Nublocks was founded in California to provide high quality nucleosides and phosphoramidites for drug development research. Initially begging with a focused offering nucleoside triphosphate conversion for biology research groups for their nucleic acid-based drug discovery. As the research demands evolve, so have we. NuBlocks have since expanded its portfolio to offering over 1000 different nucleobase analogs. We create the buliding blocks for your mRNA solution so you can stay focused on effective drug discovery and delivery. This service has allowed researchers to fine-tune their nucleic acid building block properties for the best stability, enzymatic activity, and medical efficiency. Our nucleoside phosphates have accelerated the drug discovery for both pharmaceuticals and university research groups. NuBlocks promises to never compromise on quality, delivery time and price.

Illustration of builders constructing a DNA helix using various colored building blocks.
NuBlocks

Tailored nucleic acid solutions

Analysis and purification

Provide analysis using tools such as HPLC and NMR. Novel multiple column purification process scalable to purify on the kg scale. Experts in the chemistry and data analysis for nucleic acids. 

Nucleoside conversion

Provide us with a nucleoside and we will phosphorylate, purify and ship it back quickly with analysis. Custom triphosphates and phosphoramidites are also available. Contact us to discuss what target compound you had in mind.

Nucleic acid research

We have completed many research projects in the past developing new synthetic procedures. Co-transcriptional capping, solid state support and universal linkers are all active research topics.

Your partner in innovation with an extensive catalogue of synthesized nucleosides

With over 30 years of experience, we understand precision matters and will work closely with you to provide high purity nucleobase analogs for your RNA and DNA work. Let us discuss your project needs so our experts can tailor solutions that fit with your research goals. Time is of the essence we promise you regular updates and timely delivery of projects. Over the decades we have become trusted suppliers for the starting compounds used in mRNA based research. Large pharmaceuticals such as Merck, GSK and Gilead are some reguar partners we are suppliers for. Tight batch to batch quality control, fast project turn over time, global shipping, and competitive pricing are some reasons why NuBlocks the nucleoside supplier of choice around the world. Contact us today to learn how we can help you in your research.

DNA helix with other chemical molecules floating in space.

Choose NuBlocks

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Building Blocks

We create custom designed nucleoside triphosphate and phosphoramidite that can't be purchased anywhere else. Our nucleosides have been used in research for mRNA therapeutics, drug discovery, sequencing technologies, and synthetic biology.

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Custom synthesis

We offer nucleoside phosphate conversion synthesis and tailor-made nucleosides for research. Purification and HPLC analysis are used to ensure quality. Custom nucleosides include additional functional groups to the base, chemistry of the ribose, fluorscent dyes, and structural modifications.

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Clear communication

Throughout the process we will communicate clearly our progress, troubles, and potentially better routes in regular intervals. We can be reached through email or phone 24/7. Timelines and regular project updates will be presented. 
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Years in business

Wide range of services that suit your research needs

NuBlocks LLC specializes in nucleoside and nucleotide chemistry, offering custom synthesis, contracted research, and high-purity nucleoside triphosphates (NTPs) and phosphoramidites. Our expertise in purification ensures the highest quality building blocks for nucleic acid-based therapeutics research. Trusted by global pharmaceutical companies and leading university research institutions, we provide both laboratory-scale and industrial-scale manufacturing. Several specialized nucleoside triphosphates and nucleoside triphosphates have been created. Collaborate with us to accelerate your innovations with precision-engineered nucleotides. Feel free to explore our services offered, contact us for any questions you may have. 

24/7 year round

Reach out to us any time

Lab or industrial scale

Our custom made nucleosides can be made on small scale for research trials or manuractured in bulk to accelerate your work progress. We can supply industrial scale for basic nucleosides and also asist in the scale up for custom synthesized nucleosides.

Quality and experience

With a deep understanding of the nucleic acid field, we guarantee our knowledge will be valuable. Product stability and purity are monitored through synthetic route. We understand the complex requirements for mRna drug development and are here with solutions.

Fast delivery times

Our project completion rate is unmatched. When we get a project, it becomes a core focus of ours. Communication is critical and we can be reached 24/7. NuBlocks promises clear status reports and a rapid turn around time all while maintaining a high quality product.
Science image with the Nublocks logo and text.

Our numbers

Decades of experience

Being in the business of nucleoside, nucleotide and phosphramidite chemistry for decades has established us with a wide range of products and customers.

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Years of experience
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Catalogued products
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Projects completed