NuBlocks nucleic acid services
Nucleosides and nucleotides are essential components in nucleic acids, they form the building blocks for DNA/RNA. Nublocks has an advanced skillset in creating these building blocks to assist you in your research and discovery. Explore our services and see how we can help you.
Dedicated experts
Our team of scientists have several decades of experience in the chemistry of nucleosides.
Building blocks
Our custom nucleoside and phosphoramidites will accelerate your mRNA research.
Tailored solutions
We directly collaborate with clients to develop solutions that meet their specific application.
Rapid delivery
Our efficient production processes leads to quick turnaround without compromising on quality.
Modifications
From standard phosphoramidites to complex modified structures, we have a solution for you.
Explore our services
Custom Synthesis
analysis purification
Manufacturing
Research
Nucleoside triphosphates and phosphoramidites definitions
Nucleoside phosphates are the molecular precursors to both RNA and DNA. They act as an energy source for cellular reactions and signaling pathways. Nucleoside analogs have been used to treat viral infection such as HIV.
Nucleoside phosphoramidites are derivatives of nucleosides used as building blocks for oligonucleotides. These modified oligonucleotides are used as therapeutic and diagnostic agents that can block gene expression.
Custom Synthesis
Explore our custom synthesis of nucleoside triphosphates
We offer tailored synthesis of nucleoside triphosphates, including both natural and modified nucleotides. Our team of expert chemists works closely with clients to design and produce NTPs that meet specific research needs.Our production process ensures that all synthesized NTPs meet stringent purity criteria, making them suitable for sensitive medical research applications.
Explore our custom synthesis nucleoside phosphoramidites
Custom phosphoramidites are essential making of DNA and RNA oligonucleotides. These are then used in genetic research, diagnostics, and therapeutics. Our synthesized nucleoside phosphoramidites have been used in both pharmaceutical drug discovery and university based research. NuBlocks provide support and consultation services to optimize their use in clients projects.
Contact us for custom synthesis
Over the last 20 years, our commitment to innovation and quality has led us to develop over 1,000 different nucleosides with modifications at the sugar, base, and phosphate levels. These modified nucleosides have been instrumental in advancing drug discovery, diagnostics, gene sequencing, and biological research. Our expertise and dedication have earned us a reputation as a trusted partner among leading pharmaceutical and biotechnology companies. Some of our clientelle:
Pharmacet anti-viral was acquired by Gilead for $11 billion
Idenix pharmaceutical was acquired by Merck for $3.8 billion
University clients: Harvard, University of Washington, Ottawa University
Analysis and Purification
Our Process
Nucleoside purification
Purify
Purification using our specially developed series of column purifications. Purification process is checked with HPLC. More advanced structures can be further confirmed with NMR. Can purify on kilogram scale.
1.
Analyze
Data collection and analysis using HPLC, Mass spec, and NMR. The final product will be kept frozen followed by a stability check. Custom synthesis allows for volume and container of customers choice.
2.
Finished
Send your purified product back with constant updates and data reports. Product is shipped quickly with dry ice if needed. Open to discussion or data interpretation on request.
3.
Our analytical capabilities
NuBlocks has the analytical capabilities to both purify and characterize nucleic acids. Using chromatographic techniques we can isolate nucleosides in quantities of milligrams all the way up to kilograms. Our purification process ensures the highest quality backed by chemical assay.
Our analysis capabilities include: absorption spectroscopy, HPLC, NMR, and mass spectrometry. Our analytical service will provide detailed insights into the chemical composition and purity of your nucleosides. Contact us to discuss our analysis and purification services.
Nucleoside Manufacturing
Check out our nucleoside manufacturing services.
Manufacturing
If there is a nucleoside triphosphate or nucleoside phosphoramidite you need in bulk scale, we can manufacture in large quantities at a discount rate.
Quality control
We are also able to purify nucleic acids on large scale using column chromatography. NuBlocks has proprietary designed ultra-large columns.
Scale up
We also do scale up research for manufacturing. All parameters are tested to see feasibility of scale up before moving onto a pilot plant.
Manufacturing
With our manufacturing capabilities we are able to synthesize and purify large quantity batches. If there is a nucleoside complex required in substantial scale, discuss our ability to provide. Our facilities are equiped to process nucleosides with stringent quality control standards. Contact us on our nucleoside scale up service.
Large scale manufacturing capability for the nucleoside you need
Large scale purificatoin process ensures consistency even in manufacturing scale.
Commitment to quality catering to the needs of pharmaceutical level research.
Nucleic Acid Research
See our different ongoing research projects and how we can do contracted research for your needs
Years of experience
Lets talk about your next project
Contact: info@nublocks.net
Our Research
NuBlocks chemistry of nucleic acids research
Our main focus is researching the chemistry behind synthesizing nucleosides and nucleotides. We have a wide interest in the field with research projects focused on oligonucleotides and mRNA. See some of our research projects and their progress below.
Research
NuBlocks research interests include novel synthesis methods, solid support for oligo production, improved dna/rna purification techniques, and other various nucleic acid based projects. Our team have been actively researching nucleic acid s forcience over 20 years. We have collaborated with academic institutions, research organizations, and industry partners to drive innovation and expand nucleoside chemistry. The synthetic processes developed over the years have lead to the creation of thousands of nucleoside triphosphates and nucleoside phosphoramidites. Many of the nucleosides being used and tested by some of the worlds largest pharmaceutical companies. Contact us to discuss our research and collaboration opportunities.
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