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Our dedicated chemistry team actively explores and develops novel methods for the synthesis, modification, and purification of nucleoside and nucleotide analogs. We aren't just a simple supplier, our research refines the building blocks that power modern nucleic acid based drug discovery.

NuBlocks Research

Nucleoside research service

With over 20 years of experience and a portfolio of more than 1,000 synthesized nucleoside analogs, we continuously expand our capabilities through internal research and development initiatives aimed at pushing the boundaries of nucleoside and oligonucleotide chemistry.
Our dedicated chemistry team actively explores and develops novel methods for the synthesis, modification, and purification of nucleoside and nucleotide analogs. We aren't just a simple supplier, our research refines the building blocks that power modern nucleic acid based drug discovery.
With over 20 years of experience and a portfolio of more than 1,000 synthesized nucleoside analogs, we continuously expand our capabilities through internal research and development initiatives aimed at pushing the boundaries of nucleoside and oligonucleotide chemistry.

NuBlocks research

Nucleoside research service

Synthesis
Our main research is discovering new chemistry to synthesize nucleosides and nucleotide. We have explored thousands of modifications and synthetic routes.
Oligonucleotide
Oligonucleotide research focal point is high loading solid support manufacturing. Other projects study solid support linker molecules and dna synthesis.
Our Interests
Purification
Finding new ways to purify ]nucleic acid compounds including: nucleoside, nucleotide, phosphoramidite, triphosphates, and DNA strand separation.
Analyze purification
Parallel to our synthesis investigations, we are finding new ways to analyze and purify different modified nucleosides. These methods are scalable by design.

Contracted
research

NuBlocks is your research and development partner

With our innovations in nucleic acid synthesis, a research partnership means you will reliably uncover the specific molecule that is impactful to your work. We are leading providers of novel building blocks used in the discovery of new mRNA, DNA, and other nucleic acid based therapeutics.

Over 20 years of experience and a portfolio of more than 1,000 synthesized nucleoside analogs, we continuously expand our capabilities through internal R&D initiatives aimed at pushing the boundaries of nucleoside and oligonucleotide chemistry.

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Years of nucleic acid chemistry research.

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Nucleoside compounds synthesized

Research driven to translate scientific queries into results

Nucleoside research

Nucleosides and nucleotides form the core structural units of DNA and RNA, playing critical roles in essential biological processes such as replication, transcription, and translation. Their modifiable chemical frameworks continue to stimulate advancements in both medicinal and synthetic chemistry. Nucleoside analogs represent a major class of antiviral and anticancer agents, comprising nearly half of all approved antiviral drugs. NuBlocks’ chemistry research addresses the growing demand for chemically engineered nucleotides in mRNA-based vaccines and therapeutic platforms. Active projects include the creation of nucleotide analog libraries and the evaluation of various capping strategies. Ongoing efforts also focus on the development of novel synthetic methodologies for nucleoside triphosphates and phosphoramidites across a wide range of structural modifications. Our contracted research service guarantees you get the key molecule to push your work progress forward. Contact us today.

Oligonucleotide research

Oligonucleotides are short, synthetic strands of polymeric nucleic acids with broad utility in molecular biology, including applications as PCR primers, gene expression probes, antisense agents, and sequencing reagents. NuBlocks utilizes advanced DNA synthesizers to evaluate proprietary nucleoside phosphoramidites in oligonucleotide synthesis research. Current investigations include the development of novel functionalized solid supports, such as modified silicon-based substrates and engineered polymer resins, designed to enhance loading capacity and synthesis efficiency. Research also focuses on optimizing surface activation protocols and assessing linker stability across diverse synthesis environments. Ongoing efforts involve the design and synthesis of innovative universal linkers tailored for solid-phase DNA assembly. A new high-loading solid support platform for oligonucleotide synthesis is currently in final development stages and will be commercially available soon.

Expanding nucleoside frontiers

NuBlocks research and development strategy is driven by scientific rigor, customer satisfaction, and real-world chemistry application. We routinely: develop new synthetic routes, chemical studies of new modifications (sugar, phosphate, base, linker and label), investigate oligonucleotide solid supports and optimize nucleic acid purification. Engaging in a joint development project means you gain full access to our internal nucleoside library alongside a team of dedicated chemists. Contact us and we can bring decades of innovation to your project

Chemical synthesis research is always ongoing.

Oligonucleotide including solid state support is reaching final stages

Smaller research project focuses on purifying and analysis.