Chemical analysis and purification services
See if we have what you need.
How our purification and analysis works
The purification of nucleosides and nucleotides is a challenging task. We can purify from milligram up to kilogram scale. Our laboratory is fitted with a complete variety of custom made columns with our own developed resins. Our purification system was developed over decades and ensures the highest grade of compound purity output. The analysis side is backed with PhD chemists who can provide a comprehensive chemical analysis of your starting compound and final product.
Crude analysis
Analyze the crude product to determine any precautions/molecule stability
Chemical analysis
HPLC, LC-MS, and other chemical analysis are employed
Starting compound
This can be customer provided or synthesized by us, we can also perform chemical modifications
Purify
Specially designed series of columns are used to purify the compound
Final product
Product is properly packaged before being shipped back to the customer for their research purpose.
Nucleic acid precision is our standard
We offer advanced purification and chemical analysis services tailored for nucleosides, nucleotides, oligonucleotides, and modified nucleic acids. These services are designed to support your drug discovery, therapeutic development, or research. Our workflow has been refined to deliver high purity compounds so you can be sure your results are reliable. Proper analytical data plays the critical role in research phase planning, regulatory submissions, preclinical testing, and manufacturing process development. By choosing NuBlocks as your partner, you gain access to a team that deeply the chemistry of nucleoside analogs and triphosphates.
Purification
Chemical impurities in the final compound can negatively impact biological testing results. This inconsistency leads to unreliable data which halts a projects progress. Our purification can work on both small-scale custom synthesis and large-scale production, ensuring purity and consistency at every step. NuBlocks utilizes in-house developed methodologies to remove process-related impurities, unreacted starting materials, and structural byproducts.
- High performance liquid chromatography using custom made columns and resins fit for both normal-phase and reverse-phase chromatography
- High performance ion-exchange, and desalting chromatography are also used to separate different triphosphates by charge.
- Enantiomeric or chirality based separation can also be done with molecular design discussed before hand.
- Recrystallization, trituration and other precipitation methods may be used if appropriate.
Analysis
Chemical analysis is central to ensuring the identity and purity of every nucleoside-based compound we produce or isolate. NuBlocks analytical team utilizes a diverse array of advanced instrumentation and validation techniques to produce accurate results. Each class of nucleic acid molecule—nucleoside, nucleotide, or oligonucleotide—presents unique analytical challenges. We have methods to correctly address their physicochemical differences and resolve structural complexities.
- Liquid chromatography mass spectrometry for molecule detection
- Absorption spectroscopy for further molecule detection and concentration
- pH and stability tests
- P and H nmr for structural confirmation